Study onLipid Profile of Blood and Bile in Patients with Gall Stone Disease

Abstract

Background Cholelithiasis is the commonest disease affecting the gall bladder,
which is a major cause of upper abdominal emergencies1the aim of our study is to
determine the levels of various lipids in serum and bile viz. cholesterol, triglycerides,
HDL-cholesterol, Low Density Lipoprotein (LDL)-cholesterol, and phospholipids in
patients of cholelithiasis and in control subjects and to critically analyze these
estimations and to make observations as to their role in the etiopathogenesis of
gallstones material and methods The present randomized prospective observational
study was conducted on a total of hundred cases which included half in the study
group and the other half in the control group results The serum cholesterol levels in
study group had a mean value of 161.54mg% while the control group had
156.78mg% which was statistically not significant Serum phospholipids levels in
study group had a mean value of 166.59mg%while it was found to be 121.06mg% in
control group Conclusion the plasma triglyceride value may possibly be a biological
marker of susceptibility to gallstone disease. Among those prone to stone formation,
increased exposure to a causal factor such as diet or oral contraceptive, may result in
a raised plasma triglyceride concentration together with formation of gallstones early
in life.