UTILITY OF SHEAR WAVE ELASTOGRAPHY IN EVALUATING RENAL STIFFNESS AND CORRELATION WITH BIOCHEMICAL PARAMETERS IN CHRONIC KIDNEY DISEASE PATIENTS

Abstract

AIMS AND OBJECTIVES: To explore the ability of shear wave elastography
(SWE)-derived Young’s modulus (YM) as a marker for detecting abnormal renal
parenchyma in patients with impaired estimated glomerular filtration rate (eGFR)
and biochemical parameters.
To use SWE to detect the severity of renal fibrosis
To compare elastography data between renal disease patients and healthy controls
MATERIALS AND METHODS:
This is a prospective study conducted on 30 CKD patients and 40 control
subjects .kidney length and cortical thickness are measured using conventional
ultrasound .Renal cortical stiffness was measured by performing shear wave
elastography. SWE and conventional ultrasound are correlated with creatinine urea
level and eGFR .This study was conducted at ASRAM medical college for a period
of 6 month(JUNE 2024 TO NOV 2024).
MACHINE :Mindray RESONA I9
INCLUSION CRITERIA :
CONTROLS:serum creatinine 0.6 to 1.1 mg/dl, serum urea 17-43 mg/dl,eGFR of
(>90ml min–1/1.73 m2)
renal cortex to skin surface depth of less than 7 cm, who controls their breathing
CASES:
CKD caused by various etiologies
abnormal eGFR (<90 ml–1min/1.73 m2)
Dearranged biochemical parameters, renal cortical thickness > 1cm
EXCLUSION CRITERIA for CASES AND CONTROLS :
Obese patients ,who are unable to control their breathing
who refused to give consent for the study
renal cortical thickness <1cm
RESULTS :
A total of 70 individuals were included in the study, with 40 participants as controls
(GFR > 90ml/min ), having a mean KPa of 4.62. The remaining 30 participants
were patients with chronic kidney disease (CKD), classified as follows:
- 50% were in CKD Stage 2 with a mean KPa of 6.51.
- 27% were in CKD Stage 3 with a mean KPa of 7.3.
- 17% were in CKD Stage 4 with a mean KPa of 9.2.
- 6% were in CKD Stage 5 with a mean KPa of 11.4.
AIM AND OBJECTIVES:
- To explore the potential of shear wave elastography (SWE)-derived Young’s
modulus (YM) as a marker for detecting abnormal renal parenchyma in patients
with impaired estimated glomerular filtration rate (eGFR) and biochemical
parameters.
- To detect the severity of renal fibrosis using SWE.
- To compare elastography data between renal disease patients and healthy controls.