COMPARISON OF CHLOROPROCAINE AND BUPIVACAINE FOR SPINAL ANAESTHESIA AT A TERTIARY CARE HOSPITAL: A DOUBLE BLIND RANDOMIZED CONTROLLED STUDY

Abstract

Background: Anesthesiologists are facing an increasing demand for a fast-acting, predictable anesthesia and a rapid discharge to address the increase in day care surgery. The introduction of new pencil-point spinal needles has led to the popularity of spinal anesthesia in day care settings. The current study was conducted to compare the recovery from anesthesia and the time required to achieve discharge readiness criterion between 1% 2-Chloroprocaine and 0.5% Bupivacaine in spinal anesthesia.
Materials and Methods: 60 patients between the ages of 18 and 60 who were in the ASA I and ASA II categories and were having lower abdomen, perineal and gynecological surgeries, and lower limb surgeries that was anticipated to take less than 60 minutes were chosen. The subjects were divided evenly into two groups using the double blinded randomization approach, and they were administered either 0.5% buprevacaine or 1% 2-chloroprocaine. The onset and duration of sensory and motor blockage, recovery characteristics, and adverse effects of the two medications were compared.
Results: When compared to Group B (5.76 ± 1.45), Group C's time of sensory block onset was faster (4.12 ± 1.10 minutes). When compared to Group B (7.86 ± 1.86 minutes), Group C's motor block began sooner (5.06 ± 1.71 minutes). When compared to group C (14.12 ± 3.75 minutes), Time to reach peak sensory level-T7 was longer in group B (15.12 ±3.85minutes). When compared to group C (135.18 ± 21.18minutes), group B's Time to reach sensory regression was longer (261.00 ± 32.06 minutes). When compared to group C (78.28 ± 9.96 minutes), group B's Time to reach motor regression was longer (127.54 ± 16.28minutes). When compared to Group C (182.68 ± 16.18 minutes), Group B's time to ambulation was longer (248.64 ± 19.86 minutes). When compared to Group C (194.56 ± 14.78 minutes), Group B's length of stay was longer (298.87 ± 15.86 minutes).
Conclusion: Intrathecal 1% 2-chloroprocaine 40 mg offers sufficient spinal anesthesia duration for outpatient procedures, with the benefit of markedly expedited recovery of sensory and motor functions relative to 0.5% hyperbaric bupivacaine 10 mg. Consequently, we ascertain that 2-chloroprocaine offers spinal anaesthesia with a more expedited recovery profile than bupivacaine, facilitating faster hospital release after day care procedures