STUDY OF VITAMIN-D STATUS IN PATIENTS WITH ESSENTIAL HYPERTENSION

Abstract

Vitamin D, a fat-soluble vitamin is produced when ultraviolet rays from sunlight
strike the skin. Vitamin D deficiency has been found to contribute to various
cardiovascular and cerebrovascular diseases in many ways such as hypertension,
coronary artery disease, stroke and atherosclerosis. There is a interrelation between
low serum vitamin D levels and pathogenesis of cardiovascular diseases and arterial
hypertension. Studies have shown that lower circulating 25(OH)D levels were
associated with higher blood pressures. Hypertension is one of the most important
risk factors for cardiovascular disease, which is the major cause of morbidity and
mortality worldwide. Hypertension is classified as either primary (essential) or
secondary hypertension. About 90– 95% of cases are categorized as primary
hypertension, defined as high blood pressure with no obvious underlying cause.
Aim of the study is to know the correlation between serum vitamin D3 levels and
blood pressure in patients with essential hypertension and normotensive individuals.
Material and methods: The study was conducted on 50 individuals. Individuals
are divided in to two groups. Group 1: comprising 50 patients with essential
hypertension and Group 2: comprising of 25 healthy age and sex matched
normotensive individuals.
RESULTS: We evaluated the Blood Pressure in Vitamin-D deficient subjects (Case
and Control Group), in Cases group SBP was mean 158.54 ±12.58 and in Control
Group Systolic Blood Pressure (SBP) was mean 128.53 ±6.52, P-Value is
0.0001.Individuals in cases group had high SBP recording than control group and
also in cases group mean Diastolic Blood Pressure (DBP) was96.35 ±08.13 and in
Control Group mean DBP was 86.38 ±4.13, P-Value is 0.0001, indicating case group
had high mean DBP than control group. We also found Mean SBP and DBP was
found to be high in patients with Vitamin D insufficient group than controls.
CONCLUSION: In present study involving total 50 Hypertensive patients and 25
normotensive Healthy volunteers of same age, were enrolled as a control group. In
Case group, in vitamin-D sufficient level patients have good controlled SBP then
compare other patients. In vitamin-D deficient patients and insufficient patients had
high mean SBP and DBP P-Value was 0.004 statistically significant.