ANALYSING THE EFFICIENCY OF TRANSDERMAL BUPRENORPHINE PATCH OF 10 MICROGM/HOUR IN PATIENTS RECEIVING GENERAL AND REGIONAL ANESTHESIA PRIOR SIX HOURS TO SURGERY

Abstract

The present study was carried out in 60 Patients of age 20-50 years with ASA grade I & II of either sex. The following are the important observations done during the study: Patients receiving transdermal buprenorphine patch 10 microgm/hour 6 hours before surgery had shown the following outcome: The average age in Group A was 36.47±7.74 years, while in Group B, it was 37.00±6.41 years. Regarding gender distribution, the majority of participants were female (90.0%). Specifically, Group A consisted of 24 females (80.0%), whereas all 30 participants in Group B were female (100%). Further, a statistically significant change (p<0.05, ANOVA test) was observed in heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and mean RPP (HR*MAP), all of which remained within clinically acceptable limits. Additionally, the average VAS score was low across participant groups. In Group A, the score decreased by the 6th hour, while in Group B, it reached 2.0 immediately after the postoperative period. Mean total post-operative analgesic requirements among the participants of group A and B were observed to be 660 and 595 mg respectively. Hence, the application of a transdermal buprenorphine patch at a dose of 10 mcg/hour, administered six hours before surgery, effectively provided analgesia for patients undergoing surgery under both general and regional Anesthesia. Pain scores remained below 3 after 30 hours postoperatively, and the need for rescue analgesics was reduced. Additionally, no significant adverse effects were reported, and there were no cases of bradycardia or hypotension throughout the study.