COMPARISON OF VITAMIN D LEVELS IN PATIENTS OF LUTS WITH AND WITHOUT BPH

Abstract

Background: Lower urinary tract symptoms (LUTS) in aging males are commonly attributed to benign prostatic hyperplasia (BPH). Emerging evidence suggests that Vitamin D may influence prostate health through its anti-inflammatory, immunomodulatory, and anti-proliferative effects mediated via Vitamin D receptors in prostatic tissue. Objective: To assess the association between serum Vitamin D levels in males with LUTS, comparing those with and without BPH. Methods: A hospital-based case-control study was conducted by Biochemistry Department in collaboration with Urology Department at SMS Medical College, Jaipur. A total of 120 male patients aged 50–75 years presenting with LUTS were recruited. Sixty patients with BPH (confirmed by ultrasound and PSA < 4 ng/ml) formed the case group, while 60 age-matched LUTS patients without BPH served as controls. Serum Vitamin D levels were measured using chemiluminescence method, and levels <20 ng/ml were considered deficient. Statistical analysis was performed using Student’s t-test and chi-square test. Results: The mean age in LUTS without BPH Cases group was 61.57 ± 6.27 years which was slightly lower than LUTS with BPH cases group (62.35 ± 7.58 years). This difference was statistically not significant (p value =0.6169). The mean Serum Vitamin D levels for LUTS with BPH cases was 13.98 ± 5.90 ng/ml which was significantly lower (p value < 0.05) than the serum vitamin D levels in patients of LUTS without BPH which was 18.83 ± 7.04 ng/ml. Mean Serum PSA levels for LUTS without BPH Cases was 2.09 ± 1.05 ng/ml and for LUTS with BPH Cases was 2.71 ± 0.98 ng/ml which was significant statistically (p value < 0.05). The mean value of Serum PSA was slightly higher for LUTS with BPH Cases when compared to LUTS without BPH Cases Conclusion: A significant association was found between Vitamin D deficiency and the presence of BPH among men with LUTS. These findings suggest a potential role of Vitamin D supplementation in the prevention or management of BPH-related LUTS.