Comparative study of anti-inflammatory effect of diclofenac and aceclofenac in a tertiary care centre

Abstract

Various exogenous and endogenous stimuli incite a complex reaction in vascularized
connective tissue called inflammation. Non steroidal anti inflammatory drugs are
used to reduce inflammation. Preferential COX-2 inhibitors namely diclofenac and
aceclofenac was taken for my present work and anti inflammatory effect was
compared with control and with each other. Student-t-test-was done to compare
result. It was found that inflammation varied significantly across the three groups
(P=.000) Compared to control, inflammation was less in both diclofenac and
aceclofenac (P=.00). Reduction of inflammation with diclofenac was less. In
comparision to aceclofenac at end. Aceclofenac is more efficacious than diclofenac.