Prevalence and Antimicrobial Susceptibility Patterns of Uropathogens in a Tertiary Care Centre in Prayagraj, Uttar Pradesh: A Cross-Sectional Study

Abstract

Urinary tract infections (UTIs) are a major public health concern as antimicrobial resistance among the uropathogens is on a rise. Aim- This cross-sectional study aimed to determine the prevalence and antimicrobial susceptibility patterns of uropathogens in a tertiary care center in Prayagraj, Uttar Pradesh, from December 2022 to May 2023. Methods- A total of 1477 urine samples were analyzed, with 357 samples showing significant bacterial growth on Cystine Lactose Electrolyte-Deficient (CLED) media were further processed of antimicrobial susceptibility by Kirby Bauer disc diffusion method following CLSI M-100 guidelines. Findings- The prevalence of UTI was 24.2%. Escherichia coli (58.3%) was the most common uropathogen, followed by Klebsiella pneumoniae (18.5%) and Enterococcus spp. (9.8%). Antimicrobial susceptibility testing revealed high resistance to ampicillin (82.4%) and cotrimoxazole (78.6%), while amikacin (84.3%) and nitrofurantoin (79.6%) showed better susceptibility. Multidrug-resistant (MDR) strains were observed in 88.5% of isolates. Conclusions- These findings highlight the need for local antimicrobial susceptibility data to guide empirical therapy and combat antimicrobial resistance in this region. Keywords: Urinary tract infection, uropathogens, antimicrobial susceptibility, multidrug resistance.