A STUDY OF CHEMERIN FOR THE EARLY PREDICTION OF GESTATIONAL DIABETES MELLITUS

Abstract

Gestational diabetes mellitus (GDM), a common metabolic disorder in pregnancy, poses risks to both maternal and fetal health and is associated with future development of type 2 diabetes mellitus. Recent studies suggest that biomarkers such as Chemerin—regulators of intestinal permeability and metabolic processes—may play a role in the pathogenesis of GDM. This prospective case-control study aimed to evaluate the predictive role of Chemerin in GDM and to analyze associated biochemical parameters including glucose, insulin, HbA1c, HOMA-IR, serum creatinine, ALT, and AST. Conducted at Janana Hospital, JLN Medical College, Ajmer, the study included 160 pregnant women categorized into GDM cases and healthy controls based on OGTT results. Results indicated significantly elevated levels of Chemerin in GDM subjects, correlating positively with insulin resistance and hyperglycemia. These findings support the potential of Chemerin as early predictive biomarkers for GDM, highlighting their utility in risk assessment and early intervention strategies.