Study To Evaluate the Effect On The Onset Of Sensory & Motor Block Under Spinal Anaesthesia: A Randomised Comparison Between Bupivacaine Versus Combination Of Bupivacaine and Clonidine

Abstract

Clonidine is considered as an efficient spinal anesthesia that enhances the sensory and motor blockade thereby prevention of post-spinal shivering, anxiolytic properties, and sedation. We have analyzed the effect of preoperative clonidine on the onset of sensory & motor block under spinal anesthesia. Ninety cases were registered to carry out this prospective, randomized double-blinded, placebo-controlled, single center comparative study at medical college level. Each thirty patients were placed in to two groups B and C, administered with 0.5% hyperbaric bupivacaine 3ml (15mg) & 25 micrograms Clonidine intrathecally and 0.5% hyperbaric bupivacaine 3ml (15mg) & 50 micrograms Clonidine intrathecally respectively. Control group A received 0.5% hyperbaric bupivacaine 3ml (15mg) & 0.5ml normal saline intrathecally. Patients were monitored for occurrence of side effects and complications during intra operative & postoperative period. Since the cases were randomly allocated to the respective groups, physical parameters like age, height, weight, duration of surgery and sex ratio in all the 3 groups was comparable and statistically not significant. Difference in onset of sensory and motor blockade was observed to be not significant on analysis.