A STUDY ON ASSOCIATION BETWEEN METFORMIN THERAPY AND VITAMIN B12 DEFICIENCY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A CROSS-SECTIONAL ANALYSIS

Abstract

Background: Metformin is a cornerstone in the treatment of type 2 diabetes mellitus (T2DM). However, long-term use has been linked to vitamin B12 deficiency. Objective: To assess the association between metformin therapy and vitamin B12 deficiency among patients with T2DM. Methods: A cross-sectional study involving 54 T2DM patients on metformin was conducted. Vitamin B12 levels were measured and correlated with metformin use duration and dosage. Results: Among the 54 participants, 31.5% showed B12 deficiency. Longer duration (>4 years) and higher daily dosage (>1000 mg) of metformin were significantly associated with deficiency (p<0.05). Conclusion: Vitamin B12 deficiency is prevalent in T2DM patients on metformin, especially with prolonged use and higher dosage, suggesting the need for regular monitoring.