A CLINICOPATHOLOGICAL STUDY OF CHRONIC LIVER DISEASES IN CHILDREN

Abstract

BACKGROUND: Since chronic liver disease (CLD) is linked to a number of leading causes of death and morbidity in children, it is critical to diagnose it early and accurately. When diagnosing chronic liver illnesses in children, liver biopsies continue to be crucial. The goal of the current research was to assess the clinicopathological manifestations of many chronic liver disorders in children.
MATERIALS AND METHODS: This was a prospective study carried out in a tertiary care hospital. A total of 50 children aged 1 to 14 years who presented with chronic liver illness underwent liver biopsy. Relevant investigations were completed. The treatment was carried out under strict aseptic conditions after the patient's parents provided written informed permission. The biopsy specimen was collected in formalin and forwarded to histopathology for examination. An experienced pathologist was chosen to examine these biopsy specimens. The biopsy results were examined.
RESULTS: Majority of the patients were between 1 to 8 years of age as 30 (60%) were categorized in this age group. Out of the 50 patients,30 (60%) were male and 20 (40%) were females with male to female ratio of 1.6:1. Most common clinical presentation was icterus seen in 42 cases (84%). Chronic hepatitis was the most common diagnosis identified on liver biopsy as 58% patients had histopathological findings consistent with chronic hepatitis
CONCLUSION: Since the prevalence of chronic liver disease in children is lower than that of other illnesses, a very high index of suspicion is necessary for the Chronic liver disease diagnosis in children. Without spending much time, the patients with chronic liver illnesses should be carefully checked and liver biopsy must be conducted, and rigorous follow-up should be maintained.