An Experimental study to evaluate the analgesic effect of Probenecid and Allopurinol in Swiss albino mice and it’s comparison with Tramadol using Eddy’s Hot Plate Analgesiometer

Abstract

Pain is an important symptom of gout patient. Allopurinol and Probenecid are used in
treatment of gout. Objective: To evaluate the analgesic activity of Allopurinol and
Probenecid in analgesic model of mouse. Material&Methods: the analgesic activity
of Allopurinol (200 mg/kg) and Probenecid (200mg/kg) was evaluated using Eddy’s
Hot Plate. Both the drugs were compared with control drug normal saline and
standard drug Tramadol & also among themselves. Result: Both Allopurinol and
Probenecid should significant increase in reaction time at various periods in hot plate
method. However Allopurinol has superior analgesic activity than Probenecid.
Conclusion: Both Allopurinol and Probenecid exhibit central analgesic activity